The Copernicus Cultural & Civic Center is located on the Northwest side of Chicago at 5216 West Lawrence Avenue, one block east of Milwaukee Avenue, and two blocks west of the Kennedy Expressway (I-90), Exit 84.

The Center is easily accessible by public transportation. The Lawrence Avenue bus #81 stops in front of the building. CTA and PACE buses stop at the CTA Jefferson Park bus terminal, located just two blocks northwest of the Center. METRA (Union Pacific/Northwest Line) and CTA Blue Line trains both stop at "Jefferson Park."